Immunobiologie

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Cursusdoel

Learning goals
At the end of the course you will have/be able to:
  • Insight into the function of the immune system, at the level of the book The Immune System (Parham).
  • Knowledge of selecting and processing immunological literature,
  • Master an immunological subject/problem and explore it in depth on the basis of primary literature.
  • Knowledge of the use of mathematical models and bioinformatics in immunological research.
  • A glimpse of the current state of affairs and developments in current immunological research.
Skills Part of the course Tested Explicitly?
Schrijven
Mondeling presenteren Paper en poster presentaties Ja
Omgaan met data Computer practica ja
Praktische onderzoeksvaardigheden Computer practica en poster Ja
Onderzoeksvaardigheden Computer practica en poster Ja
Samenwerken Article presentaties en poster Nee
Kritisch denken Hele cursus Ja
Loopbaanoriëntatie Gast colleges Nee
Interdisciplinariteit Hele cursus Ja

Vakinhoudelijk

Entry requirements
One of the following N2 courses of the Bachelor's degree in Biology or knowledge comparable to: The Cell, Metabolism and Biochemistry) or Developmental Biology. In addition, it is highly recommended to take one of the following N2 courses of the bachelor's degree in Biology (or otherwise obtained comparable knowledge in R programming): Data Science and Biology or Advanced Statistics and R. For MBLS students it is highly recommended to follow Bioinformatics and Dynamical Modelling course (second year).

Study path
This is a core course of the Theoretical Biology and Bioinformatics study path. The course is recommended for the study paths Cell Biology, Microbiology, Developmental Biology and Toxicology.

Language
The course is taught entirely in English as many MBLS students follow this course. All lecturers and student assistants master the Dutch language. That is why it is always possible to ask questions in Dutch.

Skills learned
  • The independent interpretation of primary research literature in immunology,
  • Being able to summarize and present complex components of immune systems and their functioning and regulation,
  • The use of basic bioinformatics and mathematical models within immunobiology,
  • Being able to use databases to find data on genes and genomes for immunological research,
  • Collaborate and arrive at a joint product (presentations and poster),
  • Writing scientific text (for the poster) and giving presentations.

Work formats
Lectures and computer exercises, article presentations and discussion sessions and a poster session at the end of the course. Blackboard page of the course is an important resource during the course. This contains all the information necessary for the course, and the assignments.

Content
The immune system includes innate and acquired defense mechanisms against (pathogenic) microorganisms. In the form of lectures, article presentations and computer exercises, you will gain step-by-step insight into the structure and functioning of the mammalian immune system.

The immune system is characterized by its great diversity. This aspect is the central theme of the course. The immunological processes and mechanisms that lead to an adequate defense against bacteria and viruses receive the most attention. For example, you will learn the structure of antibodies and the basis of antibody variability, effector functions of antibodies, functions of lymphocytes, antigen-presenting cells, and the function of proteins of the major histocompatibility complex, and immunological tolerance.

During the course you will learn to understand and analyze mathematical models and to predict with basic bioinformatics methods which parts of a virus or bacteria are the most immunogenic.

Grading & assessment
To pass this course, a minimum of 5,5 is mandatory. Your grade is calculated by the following components:
  • Tests 1&2: 60%
  • Article presentations, discussion or debate: 20%
  • Blackboard tests: 5%
  • Poster presentation: 15%
Active participation in the computer assignments is mandatory. This is tested in the form of a lab book, which must be handed in at the end of the course. The average mark for the two tests cannot be less than 5.5.

Study material
Mandatory:
  • textbook: The immune system, by Peter Parham, fifth edition, 2021, W.W. Norton & Company, ISBN: 978-0-393-53334-7 (the book is required for the course).
    Primary literature (provided during the course)

Werkvormen

Computerpracticum

Hoorcollege

Practicum

Toetsing

Eindresultaat

Verplicht | Weging 100% | ECTS 7,5

Ingangseisen en voorkennis

Ingangseisen

Je moet inschreven staan voor een van de volgende opleidingen:

  • Scheikunde
  • Biologie
  • Molecular and Biophysical Life Sciences

Voorkennis

One of the following N2 courses of the BSc Biology or knowledge comparable to: The Cell, Metabolism and Biochemistry or Developmental Biology. In addition, it is highly recommended to take one of the following N2 courses of the bachelor's degree in Biology (or otherwise obtained comparable knowledge in R programming): Data Science and Biology or Advanced Statistics and R. For MBLS students it is highly recommended to follow Bioinformatics and Dynamical Modelling course (second year).

Voertalen

  • Engels

Cursusmomenten

Gerelateerde studies

Tentamens

Er is geen tentamenrooster beschikbaar voor deze cursus

Verplicht materiaal

Materiaal Omschrijving
BOEK The immune system, by Peter Parham, fifth edition, 2021, W.W. Norton & Company, ISBN: 978-0-393-53334-7 (the book is required for the course).

Aanbevolen materiaal

Materiaal Omschrijving
ARTIKELEN Primary literature (provided during the course)

Coördinator

dr. C. Kesmir C.Kesmir@uu.nl

Docenten

dr. C. Kesmir C.Kesmir@uu.nl

Inschrijving

Let op: deze cursus is niet toegankelijk voor studenten van andere faculteiten, bijvakkers mogen zich dus niet inschrijven.

Inschrijving
Van maandag 3 juni 2024 tot en met vrijdag 21 juni 2024

Inschrijving niet geopend
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