Body-drug interactions (2023/2024: Periode 2)

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Cursusdoel

After completion of this course you have to be able to:
  1. Examine and understand the underlying relation between the main processes (liberation, absorption, distribution, metabolism, excretion, and toxicity) which determine the behaviour of a drug in the human body
  2. Analyse plasma concentration vs. time curves and calculate corresponding pharmacokinetic parameters (AUC, Co, Cmax, Vd, Ke, t1/2, tmax, F, Cl)
  3. Explain the interaction between ligands and their macromolecule targets, predict the pharmacodynamic dose-response relationship (agonist/antagonist, potency/efficacy, competitive and non-competitive drug binding) and calculate corresponding pharmacodynamic parameters (IC50, EC50, Emax, Vmax, Km)
  4. Design an appropriate experimental design and study protocol to test the proposed hypothesis
  5. Obtain, statistically analyse, evaluate and present data in accordance with good laboratory practice (GLP) standards
  6. Select and evaluate appropriate literature to compose a review on the role of ligand-receptor interactions in disease
  7. Employ appropriate communication techniques that enhance collaboration within group projects
  8. Use a strategy to self-manage your academic behaviour

Vakinhoudelijk

Most drugs are administered orally and undergo extensive modification before they ever reach their target location where they have the desired effect. What happens with the active pharmacological ingredient (API) in the body, ultimately determines the extend of the effect a drug will have. This is known as the pharmacokinetics of a drug, or in other words: what the body does to the drug. Once at the target location, an API needs to interact with the target in order to exert an effect. The types of interactions vary, as do the consequent effects. This is known as the pharmacodynamics of a drug, or in other words: what the drug does to the body. This course will cover both pharmacokinetics and pharmacodynamics. You will learn the fundamentals of pharmacology, the clinical application of these concepts and their use in cutting-edge research. Moreover, you will have the opportunity to get hands-on experience in a laboratory setting. In the initial lab skill days you will be introduced to basic lab skills and good laboratory practice (GLP). These skills can then be applied in the group lab project where you get the chance to design and execute your own experiment to answer your own research question. In addition, there will be a writing assignment with a pharmacodynamic focus in which you will learn about the role of ligand-receptor interactions in disease.
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Aanvullende informatie

Work forms
The course will be taught on the basis of self-study modules, lectures, tutorials, “meet the expert” seminars and feedback question sessions. In addition, big part of the course will consist of lab skill days and a group lab project. Before Christmas you will individually complete the lab skills days in which you get acquainted with the lab and learn the techniques needed for your own project. After Christmas, the group lab projects will start where you get to design and conduct your own experiments to answer a research question of your own choosing. Furthermore, there will be a writing assignment in which you both develop your writing skills and deepen your knowledge on the pharmacodynamic influences in disease.

Werkvormen

Communicatieonderwijs

Game

Hoorcollege

Practicum

Presentatie

Werkcollege

Toetsing

Eindresultaat

Verplicht | Weging 100% | ECTS 15

The final grade is based on assessment of your individual exams (pharmacokinetic exam 40%, pharmacodynamic exam 20%), the lab project (10%), writing assignment (20%), and your participation and attitude in the lab (10%).

Ingangseisen en voorkennis

Ingangseisen

Er is geen informatie over verplichte ingangseisen bekend.

Voorkennis

Er is geen informatie over benodigde voorkennis bekend.

Voertalen

  • Engels

Cursusmomenten

Gerelateerde studies

Tentamens

Er is geen tentamenrooster beschikbaar voor deze cursus

Verplicht materiaal

  • BOEK
    - “Principles of Pharmacology. The pathophysiologic basis of drug therapy”, D.E. Golan, A.H. Tashjian, E.J. Amstrong, A.W. Amstrong (2017), 4th edition. ISBN: 978-1451191004. Wolters Kluwer.
  • BOEK
    - “Drug Discovery and Development: Technology in Transition”, H.P. Rang (2021), 3rd edition. ISBN: 978-0702078040. Churchill Livingstone.

Aanbevolen materiaal

  • BOEK
    For physiology & anatomy you may choose one of the following books: - “Seeley’s Anatomy & Physiology”, C. van Putte, J. Regan, and A. Russo (2019), 12th edition. McGraw-Hill. - “Human Anatomy & Physiology”, E.N. Marieb & K. Hoehn (2019), 11th edition. Pearson Benjamin Cummings.

Coördinator

dr. F.M. ter Heegde f.m.terheegde@uu.nl

Docenten

dr. A.H. van Houwelingen A.H.vanHouwelingen@uu.nl

Inschrijving

Let op: deze cursus is niet toegankelijk voor studenten van andere faculteiten, bijvakkers mogen zich dus niet inschrijven.

Inschrijving
Van maandag 18 september 2023 tot en met vrijdag 29 september 2023

Inschrijving niet geopend
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