The Drug Molecule: properties and synthesis

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Cursusdoel

Course Aims
After following this course, the student is able to:
•recognize functional groups that play an important role in molecular properties like solubility, acidity, hydrophobicity, chemical stability, and interaction,
•design several basic experiments for the chemical synthesis and characterization, and biochemical analysis of drug-like derivatives,
•understand the whole process of drug design and drug development, known as the ‘drug pipeline’,
•work together, in which all aspects of team-work are incorporated.

Vakinhoudelijk

Approaches
The course ‘The Drug Molecule’ consists of three parts. The first part (weeks 1-6) is focused on theoretical aspects to understand the chemical properties of drug molecules. The second part (weeks 7-8) consists of working on the project ‘the design, synthesis, and biological evaluation of a new drug against bacterial infections’ (project I). Finally, weeks 9 and 10 focus on an overall-analysis of ‘the drug design process’, e.g. all aspects of drug design and development, as mentioned in courses A-D, should be discussed in a final project (project II).
With respect to the first part: at the beginning of each week, we will start with a ‘wicked problems?’ meeting in which the students must define their own learning goals. Tuesdays and Thursdays will be used for self-study, interspersed with feedback meetings with the teachers on a ‘when-needed’ basis. Lab-work is scheduled on every Wednesday, and there will also be possibilities to illustrate theoretical aspects by several demonstration experiments. The Fridays will be used for ‘reflection on tasks’ meetings, ‘peer and self-assessment’ sessions, and a weekly ‘summary and outlook’ discussion.
Contents
In this course you will learn to understand which chemical properties play a role in the mode of action of drugs and drug-like molecules. Topics that will be discussed include: structure of atoms and molecules, types and properties of functional groups, acid-base properties/equilibrium, reaction kinetics and thermodynamics, thermodynamics of drug binding, physicochemical properties of drug molecules (logP, logD, pKa), chemical reactivity and organic synthesis, stereochemistry and conformations, drug-target interaction, biomolecules.

Werkvormen

Hoorcollege

Practicum

Werkcollege

Toetsing

eindresultaat

Verplicht | Weging 100% | ECTS 15

The final grade is based on the written exam, project I, project II, and the individual contributions to class meetings.

Ingangseisen en voorkennis

Ingangseisen

Er is geen informatie over verplichte ingangseisen bekend.

Voorkennis

Er is geen informatie over benodigde voorkennis bekend.

Voertalen

  • Engels

Cursusmomenten

Gerelateerde studies

Tentamens

Er is geen tentamenrooster beschikbaar voor deze cursus

Verplicht materiaal

Materiaal Omschrijving
BOEK Pharmaceutical Chemistry. ISBN 9780199655304 Barber, Jill, | Oxford University Press| Druk: 1
BOEK Pharmaceutics. The science of medicine design. ISBN 9780199655311 Denton, Philip | Oxford University Press | Druk: 1

Aanbevolen materiaal

Er is geen informatie over de aanbevolen literatuur bekend

Coördinator

dr. ing. T. Wennekes T.Wennekes@uu.nl

Docenten

Inschrijving

Let op: deze cursus is niet toegankelijk voor studenten van andere faculteiten, bijvakkers mogen zich dus niet inschrijven.

Inschrijving
Van maandag 29 januari 2024 tot en met vrijdag 23 februari 2024

Inschrijving niet geopend
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