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Biochemistry
Cursusdoel
After completing this course students are able to:
- demonstrate knowledge of the chemical aspects of the structure and (patho)physiological function of various biomolecules.
- summarize the chemical basis (mechanism) of the main processes that occur in cells.
- pinpoint the important features of some diseases and extreme situations (e.g., exercise)
- write a scientific review paper focusing on the biochemical aspects of a biological subject.
In this course, the final course grade is based on four elements: two written exams, class participation and a scientific review paper.
- Written in class-exam-1: this tests your knowledge of, and ability to interpret topics described under the first two bullets of the course-goals. In more detail knowledge and insight will be tested of; i) the chemical aspects of proteins (structure and function) and enzymes (kinetics and catalytic- and regulatory strategies), ii) membranes (structure and transport processes), iii) basic metabolic strategies, iv) glucose catabolism and anabolism and v) how the cell turns food molecules into energy.
- Written in class-exam-2: this tests your knowledge of, and ability to interpret the topics describe under the first three bullets of the course goals. In more detail knowledge and insight will be tested of; i) metabolism of carbohydrates, proteins and fat, ii) lipoprotein metabolism and iii) how our body copes with pathological (diabetes mellitus) and extreme situations (e.g., exercise).
- Written scientific review paper: your mark will be built of; i) your peer-review of the paper of a colleague student and ii) the scientific review in which you show proof of your biochemical knowledge and insights, combined with a critical judgment and opinion.
- Class participation; this mark will be based on presence, class preparation and discussion during the tutorials.
Vakinhoudelijk
Biochemistry is also called ‘the chemistry of life’. It uses tools and terminologies of chemistry to unravel and understand the processes in living organisms. Knowledge and techniques generated in Biochemistry are implemented in many other fields, such as genetics, medicine, cell biology, biotechnology and immunology, thereby giving insight into the origin of many diseases and enabling the development of new chemotherapeutics and vaccines. The course can be divided into two parts. Part 1 mainly focuses on the structures and biochemical properties of proteins and basic metabolic strategies. In part 2 the knowledge obtained in part 1 will be used to study the molecular design of life. Examples from medical science will be used to illustrate how biochemical knowledge illuminates the (dys)functioning of organisms.
Format
Class meetings:
The course runs over 15 weeks and twice a week a meeting takes place (2 class hours). The theoretical part of the Biochemistry course contains 22 sessions. During each class meeting (2 hours) one session will be discussed. Students prepare for class by doing their home-study as described in the reader. Each class starts (20-30 min) with discussing home-study material and answering questions from students. Additionally, a short lecture can be part of this introductory 20-30 min. During the rest of the class students will work on tutorials, which will be discussed in class (60-70 min). Tutorials on the topics are given by means of exercises or problem-solving questions that put the topics in a biological or clinical setting.
Course book:
In addition to the introductory lectures or powerpoint handouts the corresponding chapters of the book “Biochemistry” (Tymoczko) and Human Metabolism (Frayn) are studied. These chapters provide extensive descriptive text and illustrations. Written instructions accompanying each topic are supplied.
Paper:
Students write a review paper on a biochemical topic related to one of the subjects of the course. The paper must be written in a discussion/opinion format as practiced in modern scientific journals such as ‘Trends in Biochemical Sciences’ or ‘Annual Reviews in Biochemistry’. The paper briefly describes the state of knowledge on a particular topic, combined with a critical interpretation of the data and an opinion of the student pertaining to the central question. To prepare a bibliography, the student uses literature retrieval systems to gain access to relevant papers, and explores the Internet. The students will comment on each others papers (peer review) and the papers will then be revised according to these suggestions.
The paper should give proof of the biochemical knowledge and insights, combined with a critical judgment and opinion of the students (authors).
Class meetings:
The course runs over 15 weeks and twice a week a meeting takes place (2 class hours). The theoretical part of the Biochemistry course contains 22 sessions. During each class meeting (2 hours) one session will be discussed. Students prepare for class by doing their home-study as described in the reader. Each class starts (20-30 min) with discussing home-study material and answering questions from students. Additionally, a short lecture can be part of this introductory 20-30 min. During the rest of the class students will work on tutorials, which will be discussed in class (60-70 min). Tutorials on the topics are given by means of exercises or problem-solving questions that put the topics in a biological or clinical setting.
Course book:
In addition to the introductory lectures or powerpoint handouts the corresponding chapters of the book “Biochemistry” (Tymoczko) and Human Metabolism (Frayn) are studied. These chapters provide extensive descriptive text and illustrations. Written instructions accompanying each topic are supplied.
Paper:
Students write a review paper on a biochemical topic related to one of the subjects of the course. The paper must be written in a discussion/opinion format as practiced in modern scientific journals such as ‘Trends in Biochemical Sciences’ or ‘Annual Reviews in Biochemistry’. The paper briefly describes the state of knowledge on a particular topic, combined with a critical interpretation of the data and an opinion of the student pertaining to the central question. To prepare a bibliography, the student uses literature retrieval systems to gain access to relevant papers, and explores the Internet. The students will comment on each others papers (peer review) and the papers will then be revised according to these suggestions.
The paper should give proof of the biochemical knowledge and insights, combined with a critical judgment and opinion of the students (authors).
Werkvormen
UCU sci 2 course
Toetsing
class participation
Verplicht | Weging 10% | ECTS 0,75
project essay
Verplicht | Weging 20% | ECTS 1,5
*midterm FEEDBACK*
Niet verplicht
exam I
Verplicht | Weging 30% | ECTS 2,25
exam II
Verplicht | Weging 40% | ECTS 3
Ingangseisen en voorkennis
Ingangseisen
Er moet voldaan zijn aan de cursussen:
Voorkennis
Secondary school knowledge of Mathmatics is required: B Higher Level Math, Dutch VWO "Wiskunde B" or similar "Calculus and Algebra" courses from a foreign high school.
Voertalen
- Engels
Cursusmomenten
Gerelateerde studies
Tentamens
Er is geen tentamenrooster beschikbaar voor deze cursus
Verplicht materiaal
| Materiaal | Omschrijving |
|---|---|
| BOEK | Biochemistry, A short course; Tymoczko, Berg, Stryer; W.H. Freeman & Company, New York, 3rd edition, 2015, ISBN 978-1-4641-2613-0 or 4th ed. 2019, ISBN 978-1-319-24808-6(Available trough StudyStore) |
| BOEK | Human Metabolism- A regulatory Perspective, Frayn and Evans; Wiley Blackwell, 4th edition, 2019, ISBN 978-1-119-33143-8. Book is free online available at UU-library. |
| DIVERSE | Hand out (reader) with instructions on how to study the books Biochemistry" and "Human Metabolism" (including self-test questions) |
| DIVERSE | Map of the metabolic pathways that are relevant for this course. |
Aanbevolen materiaal
Er is geen informatie over de aanbevolen literatuur bekend
Coördinator
| dr. M. Houweling | m.houweling@uu.nl |
Docenten
| dr. M. Houweling | m.houweling@uu.nl |
Inschrijving
Let op: deze cursus is niet toegankelijk voor studenten van andere faculteiten, bijvakkers mogen zich dus niet inschrijven.
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