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Mechanisms of Diseases (2024/2025: Semester 2 – Spring)

Cursusdoel

Main objective: This course discusses and explains different disease mechanisms based on the anatomical and (patho)physiologic principles of human organ systems and these will be applied to analyze various clinical cases as well as demonstrating clinical reasoning.

After completing this course students are able to:

Summarise the main anatomical, physiological and pathophysiological aspects of the major organ systems of the human body, through presentations, essays and discussions.
Analyse the signs and symptoms that indicate failing of normal human physiologic processes.
Demonstrate clinical reasoning based on pathophysiologic disease concepts and establish a diagnosis in a hypothetical patient.
Discuss and interpret social determinants of health that contribute to human diseases
Discuss pathophysiology and basic clinical presentation of important topics linked to global health: Child health; air pollution; mental health; reproductive system and maternal health.

Relationship between assessment and learning goals:

Written in-class exam 1: to analyze, anatomical, physiological, and pathophysiological aspects of gastrointestinal disease manifestations (course goals 1 to 4).,
Written in-class exam 2: to test your knowledge and ability to discuss and analyze, anatomical, physiological, and pathophysiological aspects of cardiovascular disease manifestations (course goals 1 to 4).
Written in-class exam 3: to test your knowledge and ability to discuss and analyze, anatomical, physiological, and pathophysiological aspects of respiratory disease manifestations (course goals 1 to 4).
Written in-class exam 4: to test your knowledge and ability to discuss and analyze, anatomical, physiological, and pathophysiological aspects of renal, and urinary tract disease manifestations (course goals 1 to 4).
Written in-class exam 5: to test your knowledge and ability to discuss and analyze anatomical, physiological, and pathophysiological aspects of endocrine disease manifestations (course goals 1 to 4).
Presentations in-class (15% of the final grade) and essay writing (12% of the final grade) on anatomical, and physiological aspects of major organ system of the human body and mechanisms of human diseases (course goals 3,4)
One essay (3% of the final grade) devoted to analyzing global public health topics and its influence on disease causation and progression (course goals 4,5)
Active participation (10% of the final grade) during in-class discussions and case study activities, together with personal feedback from the instructor (course goals 1 to 5)

Vakinhoudelijk

This course examines the relation between the normal functioning (physiology) and disease (pathophysiology) of seven basic organ systems:

Gastrointestinal tract
Heart and blood vessels
Upper, lower airways and the lungs
Kidneys and the urinary tract
Endocrine glands
Reproductive system
Immunology (an introduction).

To demonstrate the relation between two or more organ systems, the course ends with a study of diabetes mellitus, which is a multi-organ disorder.

Aside from these systems, the course will explore five important topics in global health and its relationship with health:

Child health
Air pollution
Mental health
Reproductive and maternal health

Format

This course will consist of interactive lectures, student presentations on embryology, anatomy and physiology, case studies or patient demonstrations and assignments. Students are expected to spend about ten hours per week on the course outside of class and complete their readings before class. Students are highly encouraged to contribute actively to class discussion and activities

Werkvormen

UCU SCI 2 course