Genomes, Cells & Tissues (2025/2026: periode 3)

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Cursusdoel

Upon successful completion of this course, students will be able to:
  1. To be able to explain the molecular properties, concentration gradients, protein-protein interactions and transport systems at the molecular and cellular level.
  2. To be able to name the function and complexity of protein interactions and signaling pathways within systems biology.
  3. Describe different molecular mechanisms of cell communication and intracellular transport.
  4. To be able to describe (the importance of) different control mechanisms in the cell cycle.
  5. To be able to name different molecular mechanisms of cancer development and cancer treatment.
  6. To be able to name the role of stem cells in tissue production and to be able to describe current developments in stem cell engineering.
  7. To be able to present the main finding from a Cell paper on one of the above topics.
  8. Provide constructive feedback to fellow students.
  9. Devise critical questions for an article and discuss them.

Vakinhoudelijk

The aim of this course is to teach the function and organisation of the animal cell and its components. From the molecular level up to and including the functioning of cells in the tissues of living organisms.

Introduction:
In the first part of this course the central dogma of molecular biology will be discussed. DNA replication, transcription, translation and its regulation. Using bioinformatics you will learn how complex the genome and the regulation of gene expression is. In the second part cell function will be discussed, such as protein sorting, membrane transport, signalling pathways and the cell cycle. In part 2 we also discuss the cooperation of cells in tissues. For example, we will discuss apoptosis, cell-cell contacts and tissue renewal by stem cells. Attention will also be paid to situations in which these processes no longer function properly, such as in cancer.

Set up of this course:
The student independently reads the book chapter by chapter. After each chapter, a sequence of e-assessments, lectures, assignments and response lectures is followed. Starting after a short e-assessment the teacher, a specialist in his field, discusses the information of the chapter in a seminar. To get a deeper understanding of the content in the chapter the students will make assignments in small groups of 4-5 students. Hereafter the teacher will be available to discuss the answers to the assignments and to clarify any misconceptions in a response lecture. The current use of the knowledge from the textbook is exemplified during a journal club, where groups of students present a Cell paper. The topic of the papers is current literature on cancer research.

Part-1: chapters 4-7 and 12 from Molecular Biology of the Cell by Alberts.
Part-2: chapters 13, 15, 17-20 and 22 from Molecular Biology of the Cell by Alberts

Relation to other courses:
This course extends on the knowledge acquired in the foundation course MBLS-101 ‘Cell Biology’. This course provides you with advanced knowledge in Molecular Cell Biology and connects well with all mandatory and elective courses within this field. Students that follow the profiles “Genes to Organisms” and “Molecules and Cells” are strongly advised to follow this course.

Teaching format course (estimation):
Lectures 20%
Tutorials / group assignments 20%
Tutorial discussions 20%
Presentation (Journal club) 10%
Self study & self-assessments 30%

Grading (see course manual for details):
test/exam part 1 (45%)
test/exam part 2 (45%)
Journal club presentation(10%)

For each of the exams and for the journal club a 5.0 is the minimal grade to pass. Attendance during the tutorials and journal clubs is mandatory. In addition the individual self-assessments are also part of the effort requirements.

Werkvormen

Hoorcollege

Inzage

Werkcollege

Werkcollege 1

Toetsing

Eindresultaat

Verplicht | Weging 100% | ECTS 7,5

Ingangseisen en voorkennis

Ingangseisen

Je moet inschreven staan voor de volgende opleiding:

  • Molecular and Biophysical Life Sciences

Voorkennis

Entry requirements: Successful completion of MBLS-101 (Cell Biology) or an equivalent level 1 course in Molecular Cell Biology. Recommended: MBLS-202 (Molecular Biology & Biochemical Techniques)

Voertalen

  • Engels

Cursusmomenten

Gerelateerde studies

Tentamens

Er is geen tentamenrooster beschikbaar voor deze cursus

Verplicht materiaal

  • BOEK
    Bruce Alberts. Molecular Biology of the Cell (7e druk). Norton & Company.
    Molecular Biology of the Cell Alberts
    ISBN: 9780393884852

Aanbevolen materiaal

Er is geen informatie over de aanbevolen literatuur bekend

Coördinator

dr. R.L.P. Habets R.L.P.Habets@uu.nl

Docenten

prof. dr. T. Baubec t.baubec@uu.nl
dr. R. Cardoso Da Silva r.cardosodasilva@uu.nl
dr. E. de Graaff E.deGraaff@uu.nl
dr. R.L.P. Habets R.L.P.Habets@uu.nl
prof. dr. S.J.L. van den Heuvel S.J.L.vandenHeuvel@uu.nl
dr. B. Kleizen B.Kleizen@uu.nl
dr. S. Santos Oliveira S.Oliveira@uu.nl
prof. dr. B. Snel b.snel@uu.nl
dr. H. Vlaming H.vlaming@uu.nl
dr. L.M. Will L.M.Will@uu.nl

Inschrijving

Let op: deze cursus is niet toegankelijk voor studenten van andere faculteiten, bijvakkers mogen zich dus niet inschrijven.

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